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Anti-Deamidated Gliadin Peptide IgG (DGP IgG Test) and its Function

The Anti-Deamidated Gliadin Peptide IgG (DGP IgG) test is a blood test that is used to aid in the diagnosis of celiac disease, an autoimmune disorder triggered by gluten ingestion. Similar to the DGP IgA test, the DGP IgG test measures the level of IgG antibodies against deamidated gliadin peptides in the blood. The function of the DGP IgG test is to help in the diagnosis and monitoring of celiac disease, particularly in individuals who may have IgA deficiency, which can result in false-negative results on the IgA-based tests.

Conditions that may require Anti-Deamidated Gliadin Peptide IgG (DGP IgG Test) Test

The Anti-Deamidated Gliadin Peptide IgG (DGP IgG) test is primarily used as a diagnostic tool for celiac disease, an autoimmune condition triggered by gluten ingestion. It is specifically helpful in situations where IgA-based tests may not be reliable due to IgA deficiency or immaturity of the immune system. The DGP IgG test may be used in the following conditions:

Suspected Celiac Disease: The DGP IgG test may be ordered when there is a suspicion of celiac disease based on clinical symptoms, family history, or other factors. It can be particularly useful in individuals who have IgA deficiency, which can result in false-negative results on IgA-based celiac disease tests.
IgA Deficiency: IgA deficiency is a condition in which an individual has low levels or a complete absence of IgA antibodies. In such cases, the DGP IgG test can be used as an alternative or additional test to help diagnose or rule out celiac disease.
Pediatric Diagnosis: Celiac disease can occur in children, and the DGP IgG test may be considered in pediatric populations when diagnosing celiac disease. It can be used alongside other tests to aid in the diagnosis process.
Monitoring: The DGP IgG test can also be used to monitor individuals with diagnosed celiac disease, especially those who had elevated DGP IgG antibody levels at the time of diagnosis. Regular testing over time can help assess treatment adherence and disease management.

Anti-Deamidated Gliadin Peptide IgG (DGP IgG Test) Test Procedure

The Anti-Deamidated Gliadin Peptide IgG (DGP IgG Test) is performed by drawing a blood sample from a vein in your arm. Our phlebotomist, will clean the site with an antiseptic and apply a tourniquet to make the veins more visible. He will then insert a sterile needle into a vein and collect the required amount of blood into a collection tube.

Interpreting Anti-Deamidated Gliadin Peptide IgG (DGP IgG Test) Test Results

Positive Result: A positive result indicates the presence of elevated levels of IgG antibodies against deamidated gliadin peptides. This suggests a higher likelihood of celiac disease, especially in individuals who may have IgA deficiency or negative results on IgA-based celiac disease tests. However, a positive result on its own is not sufficient to confirm a diagnosis. Additional diagnostic tests, such as intestinal biopsy and clinical evaluation, are typically necessary to establish a definitive diagnosis.
Negative Result: A negative result indicates the absence of detectable levels of IgG antibodies against deamidated gliadin peptides. However, it's important to note that a negative result does not definitively rule out celiac disease. Celiac disease is a complex condition, and individuals may still have the disease despite negative antibody test results. In such cases, additional testing and evaluation may be necessary.
Indeterminate Result: Occasionally, the DGP IgG test result may fall into an indeterminate or equivocal range, where it is not definitively positive or negative. Indeterminate results may occur due to various factors, including borderline antibody levels. Further testing and consultation with a healthcare professional experienced in celiac disease diagnosis may be required to clarify the interpretation.

Treatment for High Anti-Deamidated Gliadin Peptide IgG (DGP IgG Test) levels

Elevated levels of Anti-Deamidated Gliadin Peptide IgG (DGP IgG) antibodies alone do not indicate a specific treatment requirement. The DGP IgG test is primarily used as a diagnostic tool for celiac disease, an autoimmune condition triggered by gluten ingestion. If an individual has high DGP IgG levels and meets the diagnostic criteria for celiac disease, the standard treatment is a strict lifelong gluten-free diet. The primary goal of treatment is to eliminate gluten from the diet to prevent damage to the small intestine and alleviate symptoms.